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- DOI 10.18231/j.sajcrr.v.12.i.3.5
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CrossMark
- Citation
Dual infection of the esophagus in an immunocompetent individual
- Author Details:
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Deshidi Srinu *
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Amrutha Guguloth
Background: Infectious esophagitis is predominantly observed in immunocompromised individuals, with Candida albicans, herpes simplex virus, and cytomegalovirus being the most common pathogens. Dual infection involving both Candida and Herpes simplex is exceedingly rare, especially in immunocompetent individuals.
Case Presentation: 50-year-old male with type 2 diabetes mellitus and coronary artery disease presented with progressive dysphagia, odynophagia, chest pain, and weight loss for 6 months. Endoscopy revealed oesophageal ulcers and whitish mucosal plaques throughout the oesophagus. Initial histopathology confirmed Candida infection, and the patient was treated with fluconazole. Due to persistent symptoms and suspicion of other dual aetiology, a repeat endoscopy and biopsy of oesophageal ulcer was performed, which revealed histological features consistent with HSV esophagitis. Serum HSV IgG was positive, and the patient responded well to intravenous acyclovir.
Conclusion: This case underscores the importance of considering dual infections in patients with esophagitis, even in the absence of overt immunosuppression. Early endoscopic evaluation with repeat biopsies, when clinically indicated, is crucial for accurate diagnosis and appropriate treatment.
References
- Robertson KD, Nagra N, Mehta D. Esophageal Candidiasis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. Available from: http://www.ncbi.nlm.nih.gov/books/NBK537268/
- Canalejo E, García Durán F, Cabello N, García Martínez J. Herpes esophagitis in healthy adults and adolescents: report of 3 cases and review of the literature. Med (Baltimore). 2010;89(4):204–10.
- Gani I, Kosuru V, Saleem M, Kapoor R. Simultaneous candida albicans and herpes simplex virus type 2 esophagitis in a renal transplant recipient. BMJ Case Reports CP. 2019;12(8):e230410.
- Grossi L, Ciccaglione AF, Marzio L. Esophagitis and its causes: Who is “guilty” when acid is found “not guilty”? World J Gastroenterol. 2017 May 7;23(17):3011–6.
- Hoversten P, Kamboj AK, Katzka DA. Infections of the esophagus: an update on risk factors, diagnosis, and management. Dis Esophagus. 2018;31(12):doy094.
- Kingsley-Godwin D, Kingsley-Godwin MJ, Godwin J, Kingsley- Godwin D, Kingsley-Godwin MJ, Godwin J. Infectious Esophagitis. In: Esophagitis and Gastritis - Recent Updates. IntechOpen; 2021. Available from: https://www.intechopen.com/chapters/78513
- Rudramurthy SM, Singh S. Candida Infections in Immunocompetent Hosts: Pathogenesis and Diagnosis. Curr Fungal Infect Rep. 2020;14(3):233–45.
- Mohamed AA, Lu X liang, Mounmin FA. Diagnosis and Treatment of Esophageal Candidiasis: Current Updates. Can J Gastroenterol Hepatol. 2019;2019:3585136.
- Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical Practice Guideline for the Management of Candidiasis: Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1–50. 71 Srinu and Guguloth / Southeast Asian Journal of Case Report and Review 2025;12(3):67–71
- Shah R, Patel S, Henriquez R, Parikh J, Mandalia A. Herpes simplex virus esophagitis in an immunocompetent patient. Cureus. 2023;15(9):44668.
- Diezma-Martín AM, Gigante-Miravalles E, Castro Limo JD, Quimbayo Arcila CA, Puche Paniagua JJ. Herpetic esophagitis in immunocompentent host: cases report. BMC Infectious Diseases. 2020;20(1):605.
- Wang HW, Kuo CJ, Lin WR, Hsu CM, Ho YP, Lin CJ. Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan. Medicine. 2016;95(14):e3187.
- Chen LI, Chang JM, Kuo MC, Hwang SJ, Chen HC. Combined herpes viral and candidal esophagitis in a CAPD patient: case report and review of literature. Am J Med Sci. 2007;333(3):191–3.
- Sathyanarayanan V, Razak A, Prabhu MM, Saravu K, Ganesh PC, Rao AK. A case report of herpetic and candidal esophagitis in an immunocompetent adult. Asian Pac J Trop Biomed. 2011;1(3):251–
- Alicea S, Tejada N, Restrepo J, Mandalia A. A Case of Vaping- Associated Candida and Herpes Simplex Virus (HSV) Co-infection Causing Esophagitis in an Immunocompetent Patient. Cureus. 2024;16(5):e60710.
How to Cite This Article
Vancouver
Srinu D, Guguloth A. Dual infection of the esophagus in an immunocompetent individual [Internet]. South Asian J Case Rep Rev. 2025 [cited 2025 Oct 02];12(3):67-71. Available from: https://doi.org/10.18231/j.sajcrr.v.12.i.3.5
APA
Srinu, D., Guguloth, A. (2025). Dual infection of the esophagus in an immunocompetent individual. South Asian J Case Rep Rev, 12(3), 67-71. https://doi.org/10.18231/j.sajcrr.v.12.i.3.5
MLA
Srinu, Deshidi, Guguloth, Amrutha. "Dual infection of the esophagus in an immunocompetent individual." South Asian J Case Rep Rev, vol. 12, no. 3, 2025, pp. 67-71. https://doi.org/10.18231/j.sajcrr.v.12.i.3.5
Chicago
Srinu, D., Guguloth, A.. "Dual infection of the esophagus in an immunocompetent individual." South Asian J Case Rep Rev 12, no. 3 (2025): 67-71. https://doi.org/10.18231/j.sajcrr.v.12.i.3.5