Southeast Asian Journal of Case Report and Review
Official Publication of Association of Biomedical Scientists
Official Publication of Association of Biomedical Scientists
Online ISSN: 2319-1090
Southeast Asian Journal of Case Report and Review is a Peer-reviewed, International medical journal Published by the Association of Health Professionals. It will publish 04 issues per year will publish a research paper prepared by Health Professional. Journal will Give Preference to Case Report and Review Article Aim and Scope The aim and commitment of the journal is to publish a research-oriented manuscript on significant issues in all the subjects and areas of Medical Science including Genome mutation and Pathogenicity in microbes. Journal more...Case Report
Author Details :
Volume : 11, Issue : 4, Year : 2024
Article Page : 113-116
https://doi.org/10.18231/j.sajcrr.2024.027
Abstract
Background: Lynch syndrome (LS), previously known as hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant disorder that predisposes individuals to various malignancies, most commonly adenocarcinomas. While low-grade neuroendocrine tumors (NETs) associated with Lynch syndrome are rarely reported, gastric neuroendocrine tumors (g-NETs) account for less than 1% of all gastric tumors.
Report: This case report presents a rare occurrence of gastric neuroendocrine hyperplasia and dysplasia in a 68-year-old female diagnosed with Lynch syndrome. The patient, previously treated for well-differentiated adenocarcinoma of the colon, was found to have a polyp in the gastric fundus during routine surveillance. Histological analysis revealed adenocarcinoma alongside neuroendocrine cell proliferation, confirmed by synaptophysin immunostaining.
Conclusion: This case highlights a novel association between Lynch syndrome and gastric neuroendocrine hyperplasia/dysplasia. This finding raises awareness among clinicians regarding Lynch syndrome in patients with low-grade NETs or neuroendocrine precursors and underscores the need for comprehensive surveillance and further research to understand the underlying mechanisms and clinical implications. It suggests that mutations in mismatch repair (MMR) deficiency may play a role in neuroendocrine cell proliferation, expanding the spectrum of Lynch syndrome-associated tumors, and pointing to new directions for studying the molecular pathways and pathogenesis of NETs.
Keywords: Lynch syndrome, Neuroendocrine neoplasm, Low grade, Hyperplasia, Dysplasia
How to cite : Yihan Li, Gastric neuroendocrine hyperplasia and dysplasia in a patient with Lynch Syndrome. South Asian J Case Rep Rev 2024;11(4):113-116
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